http://www.echemstore.com/st005178-9-methoxy-2-2-dimethyl-6-hydro-2h-pyrano-5-6-c-quinolin-5-one.html http://www.echemstore.com/st009843-2r-3r-13r-14r-3-acetyl-15-oxo-17-19-dioxa-4-azapentacyclo-14-2-1-0-2-14-0-4-13-0-7-12-nonadeca-5-7-12-8-10-tetraene.html http://www.echemstore.com/st072199-flumequine.html

O-GlcNAc Transferase Inhibitors


 TimTec assembled small targeted compound collection of over 500 compounds-analogs based on three validated O-GlcNAc Transferase inhibitors (following the results of the discovery at Department of Microbiology and Molecular Genetics, HUMS)

Reference:

Gross, B.J, Kraybill, B.C., Walker, S. Discovery of O-GlcNAc Transferase Inhibitors. Department of Microbiology and Molecular Genetics, Harvard Medical School. JACS Communications, published on Web 09/29/05; J. Am. Chem. Soc. 2005, 127, 14588-14589.

Compounds with proven activity are available from stock:

 

ST060266

289.67

phenyl 5-chloro-2-oxo-3-hydrobenzoxazole-3-carboxylate

ST060266

 

ST078925

406.53

4-[(3-cyano-4-(2-thienyl)-2-5,6,7,8-tetrahydroquinolylthio)methyl]benzoic acid

ST078925



ST078925 analog-substitute to validated inhibitor #6, Figure 3. of the paper

 

ST045849

447.00

3-(2-adamantanylethyl)-2-[(4-chlorophenyl)azamethylene]-4-oxo-1,3-thiazaperhyd roine-6-carboxylic acid

ST045849

OGT inhibitor, ST045849, TT04, treatment reduces beta-cell development:

Reference:

Filhoulaud, G., et al. The hexosamine biosynthesis pathway is essential for pancreatic beta cell development. J Biol Chem. 2009 Sep 4;284(36):24583-94.

BioActive Scroller

ST096084 Nateglinide

ST096084 Nateglinide

Formula: C19H27NO3MW: 317.43CAS: 105816-04-4MDL NUMBER: MFCD00875706Smiles: CC(C)C1CCC(CC1)C(=O)NC(C..
ST096085 Flupirtine maleate

ST096085 Flupirtine maleate

Formula: C19H21FN4O6MW: 420.4CAS: 75507-68-5MDL NUMBER: MFCD00941415Smiles: OC(=O)/C=C/C(O)=O.CCOC(=..
ST096086 Flibanserin

ST096086 Flibanserin

Formula: C20H21F3N4OMW: 390.41CAS: 167933-07-5MDL NUMBER: MFCD00918402Smiles: FC(F)(F)c1ccc(cc1)N1CC..